Description
Melanotan II (MT-2) Dosage Protocol
Melanotan II is a synthetic analog of α-MSH (alpha-melanocyte-stimulating hormone) that activates melanocortin receptors (MC1R, MC3R, MC4R). It is primarily studied for its ability to promote skin pigmentation (tanning), while also influencing libido, appetite suppression, and energy balance.
By stimulating melanin production, Melanotan II supports UV-independent tanning, often used in conjunction with controlled sun or UV exposure for enhanced results.
This educational protocol outlines a gradual subcutaneous dosing approach to improve tolerance and minimize side effects.
Reconstitute:
Add 2.0 mL bacteriostatic water → ~5 mg/mL (5000 mcg/mL) concentration (based on a 10 mg vial)
Typical Protocol:
- Loading Phase (7–14 days):
- Start at 250 mcg daily
- Gradually increase to 500–1000 mcg daily
- Maintenance Phase:
- 500–1000 mcg, 2–3 times per week
- Use alongside moderate UV exposure for optimal pigmentation
Easy Measuring:
At 5 mg/mL,
- 1 unit = 0.01 mL ≈ 50 mcg on a U-100 insulin syringe
Example:
- 250 mcg dose ≈ 5 units
- 500 mcg dose ≈ 10 units
- 1 mg dose ≈ 20 units
Administration:
- Subcutaneous injection (abdomen preferred)
- Typically administered in the evening to reduce nausea
- Rotate injection sites
Storage:
- Lyophilized: Store at −20 °C (−4 °F)
- After reconstitution: Refrigerate at 2–8 °C (35.6–46.4 °F)
- Protect from light and avoid repeated freeze–thaw cycles
Note:
Melanotan II is commonly researched for skin tanning, libido enhancement, and appetite suppression. Some users may experience side effects such as nausea, facial flushing, or increased pigmentation (freckles/moles), especially during the initial dosing phase.
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